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string(11818) "一、基本情況
2016年中國肺癌精彩學(xué)術(shù)大賽卓越獎。2017年獲亞洲心胸外科大會頒發(fā)的Furuse Awards杰出研究貢獻獎。團隊研究成果證實，術(shù)前放化療并手術(shù)可延長局部晚期食管癌的總生存，將食管癌患者的中位生存期延長將近50%，奠定了“術(shù)前新輔助放化療聯(lián)合手術(shù)”治療模式在國內(nèi)外的地位。全球首創(chuàng)建立了立體定向放射序貫新輔助免疫聯(lián)合化療的新模式，治療中晚期肺癌，顯著提升療效，將病理完全緩解率提升至52%。2019 - 2020年通過香港優(yōu)才計劃前往香港威爾斯親王醫(yī)院胸外科交流并獲得香港行醫(yī)執(zhí)照。獲2022年“人民好醫(yī)生·金山茶花計劃”食管癌領(lǐng)域杰出貢獻專家稱號。
以第一/通訊作者在Lancet、Journal of Clinical Oncology、Lancet Respiratory Medicine、Annals of Oncology、JAMA Surgery、Nature Communication等高水平期刊發(fā)表文章40余篇。主持國家級重大人才項目、國家自然科學(xué)基金項目、廣東省科技計劃項目等，科研經(jīng)費逾千萬。Lancet Onocolgy、Lancet Respiratory Medicine、Nature Communication、Signal Transduction and Targeted Therapy審稿專家。
出診時間：越秀院區(qū)：周二?周三上午
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二、教育及工作經(jīng)歷
2020–至今??????中山大學(xué)腫瘤防治中心??胸外科??????主任醫(yī)師
2019 - 2020年???香港威爾斯親王醫(yī)院????微創(chuàng)胸外科??Fellow（香港優(yōu)才計劃）
2014 –至今??????中山大學(xué)腫瘤防治中心??胸外科?????副主任醫(yī)師
2009 - 2014年???中山大學(xué)腫瘤防治中心??胸外科???主治醫(yī)師
2006 - 2009年???中山大學(xué)腫瘤防治中心??外科??????專科培訓(xùn)醫(yī)師
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三、學(xué)術(shù)兼職
華南腫瘤學(xué)重點實驗室獨立PI
國際肺癌研究協(xié)會會員
國家健康科普專家?guī)鞂＜?國家癌癥中心食管癌質(zhì)控專家委員會華南區(qū)協(xié)作組副組長
中國抗癌協(xié)會食管腫瘤整合康復(fù)專業(yè)委員會副主任委員
中國臨床腫瘤學(xué)會(CSCO)青年專家委員會常務(wù)委員
中國抗癌協(xié)會食管癌專業(yè)委員會委員
廣東省抗癌協(xié)會食管癌專業(yè)委員會副主任委員
廣東省胸部腫瘤防治研究會靶向治療專業(yè)委員會主任委員
廣東省藥學(xué)會第一屆胸外科專家委員會副主任委員
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四、代表性論著
1. Zhou S#, Wang Y#, Zhang R#, Zeng W, Liu S, Liu S, Liu M, Yang H*,Xi M*.Association of Sialic Acid-Binding Immunoglobulin-Like Lectin 15 With Phenotypes in Esophageal Squamous Cell Carcinoma in the Setting of Neoadjuvant Chemoradiotherapy JAMA Netw Open. 2023-01-03;6(1):e2250965.
2. Zihang Mai# , Jiaxin Xie#, Changsen Leng#, Xiuying Xie, Jing Wen, Hong Yang*, Qianwen Liu*, Jianhua Fu*.An optimized post-surgery follow-up strategy for patients with esophageal cancer: a cohort study.Int J Surg. 2023 November 2.
3. Chen, Baoqing#；Liu，Shiliang#；Zhu, Yujia#；Wang, Ruixi#；Cheng, Xingyuan；Chen，Biqi；Dragomir，Mihnea P；Zhang，Yaru；Hu，Yonghong； Liu，Mengzhong；Li，Qiaoqiao*；Yang, Hong*；Xi，Mian*.Predictive role of ctDNA in esophageal squamous cell carcinoma receiving definitive chemoradiotherapy combined with toripalimab.Nat Commun. 2024-03-01;15(1):1919.
4.Rui?Chen#,?Qianwen?Liu#,?Qiaoqiao?Li#,?Yujia?Zhu#,?Lei?Zhao,?Shiliang?Liu,?Baoqing?Chen,?Mengzhong?Liu,Yonghong?Hu,?Ting?Lin,Jibin?Li,?Jiyang?Chen,?Yingxin?Lv,?Jianhua?Fu*?,?Mian?Xi*,?Hong?Yang*.A phase II clinical trial of toripalimab combined with neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma (NEOCRTEC1901).EClinicalMedicine. 2023-08-01;62:102118.
5. Jianye Yuan#, Zelin Weng#, Zihui Tan#, Kongjia Luo#, Jian Zhong, Xiuying Xie a,c Chunhua Qu, Xiaodan Lin Hong Yang*, Jing Wen*, Jianhua Fu*.Th1-involved immune infiltrates improve neoadjuvant chemoradiotherapy response of esophageal squamous cell carcinoma. Cancer Letters.?2023-01-28;553:215959.
6. Zihang Mai#, Jianye Yuan#, Hong Yang#, Shuogui Fang#, Xiuying Xie, Xinye Wang, Jiaxin Xie, Jing Wen*, Jianhua Fu*. Inactivation of Hippo pathway characterizes a poor-prognosis subtype of esophageal cancer. JCI Insight. 2022;7(16): e155218 IF:9.496
7. Jing Wen*, Shuogui Fang#, Yi Hu#, Mian Xi#, Zelin Weng, Chuqing Pan, Kongjia Luo, Yihong Ling, Renchun Lai, Xiuying Xie, Xiaodan Lin, Ting Lin, Jiyang Chen, Qianwen Liu*, Jianhua Fu*, and Hong Yang*. Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma. EBioMedicine .2022;86: 104371.
8. Hong Yang#, Hui Liu#, Yuping Chen#,?Chengchu Zhu#, ?Wentao Fang#, ?Zhentao Yu#, Weimin Mao#, ?Jiaqing Xiang#, ?Yongtao Han#, ?Zhijian Chen#, ?Haihua Yang#, ?Jiaming Wang#, ?Qingsong Pang#, Xiao Zheng#, Huanjun Yang#, ?Tao Li#, ?Xu Zhang, Qun Li, ?Geng Wang, ?Baofu Chen, Teng Mao, Min Kong, Xufeng Guo, ?Ting Lin, Mengzhong Liu*, M Jianhua Fu*.Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma. JAMA Surgery.2168-6254. 2021,156(08): 721-729.Sun?Yat-sen?University?Cancer?Center.中科院一區(qū).IF: 16.9
9. Xufeng Guo #, Zhexin Wang#; Hong Yang#, Teng Mao#, Yuping Chen, Chengchu Zhu, Zhentao Yu, Yongtao Han, Weimin Mao, Jiaqing Xiang, Zhijian Chen, Hui Liu, Haihua Yang,Jiaming Wang, Qingsong Pang, Xiao Zheng , Huanjun Yang, Tao Li, Xu Zhang, Qun Li, Geng Wang, Ting Lin, Mengzhong Liu, Jianhua Fu*, Wentao Fang*. Impact of Lymph Node Dissection on Survival after Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma. Annals of Surgery. 2023-02-01;277(2):259-266.
10. Shiliang Liu#, Jing Wen#, Hong Yang#, Qiaoqiao Li#, Yuping Chen, Chengchu Zhu, Wentao Fang, Zhentao Yu, Weimin Mao, Jiaqing Xiang, Yongtao Han, Lei Zhao, Hui Liu, Yonghong Hu, Mengzhong Liu, Jianhua Fu*, Mian Xi*. Recurrence patterns after neoadjuvant chemoradiotherapy compared with surgery alone in oesophageal squamous cell carcinoma: results from the multicenter phase III trial NEOCRTEC5010.European Journal of Cancer. 2020-10-01;138:113-121.
11. Yan Huang, ?Yihuai Hu, , Yaobin Lin，?Jianhua Fu, , Jiadi Wu, Caiyan Fang, ?Min Liu, ?and Yang Hong#.Evaluation of Fibrin Sealant in Prevention of Cervical Anastomotic Leakage After McKeown Esophagectomy: A Single Center, Retrospective Study. ANN SURG ONCOL. 2021-10-01;28(11):6390-6397. IF：4.339
12. Sha Zhou#，?Hong Yang#, ?Jun Zhang#，?Juncheng Wang, Zhaohui Liang, ?Songran Liu, Yong Li, Yanpeng Pan, MD, Lei Zhao, MD,* and Mian Xi, MD*.Changes in Indoleamine 2,3-Dioxygenase 1 Expression and CD8D Tumor-Infifiltrating ?Lymphocytes after Neoadjuvant Chemoradiation Therapy and Prognostic Signifificance in Esophageal Squamous Cell Carcinoma. International Journal of Radiation Oncology Biol Phys.2020 Jan; 108(1)286-294. IF:?8.013?
13.Hong?Yang#，?Hui?Liu#，Yuping?Chen#，Chengchu?Zhu#，Wentao?Fang#， Zhentao?Yu#，Weimin?Mao#，Jiaqing?Xiang#，Yongtao?Han#，Zhijian?Chen#， Haihua?Yang#， Jiaming?Wang#，Qingsong?Pang#，Xiao?Zheng#，Huanjun?Yang#， Tao?Li#,Florian?Lordick，Xavier?Benoit?D’Journo， Robert?J.?Cerfolio，Robert?J.Korst,?Nuria?M.?Novoa， Scott?J.?Swanson，Alessandro?Brunelli,?Mahmoud?Ismail，Hiran?C.?Fernando,?Xu?Zhang,?Qun?Li，Geng?Wang,?Baofu?Chen,?TengMao， Min?Kong，Xufeng?Guo，Ting?Lin，Mengzhong?Liu, Jianhua Fu,Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial. J Clin Oncol.?2018 Sep;36 (27): 2796-2803. ?IF:50.717
14. Li L#, Li JC#,?Yang H#, Zhang X, Liu LL, Li Y, Zeng TT, Zhu YH, Li XD, Li Y, Xie D, Fu L, Guan XY*Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis.Proc Natl Acad Sci USA.2018Sep;115(38):E8948-E8957. IF:11.205
15. Yang YF#, Zhang MF#, Tian QH#, Fu J, Yang X, Zhang CZ*, Yang H*.SPAG5 interacts with CEP55 and exerts oncogenic activities via PI3K/AKT pathway in hepatocellular carcinoma.Mol Cancer.2018 Aug;17(1):117. IF:27.401
16.?Wen Jing#,?Hu Yi#,?Liu Qianwen#,Ling Yihong,?Zhang Shuishen,?Luo Kongjia,?Xie Xiuying,?Fu Jianhua*,?Yang Hong*.miR-424 coordinates multilayered regulation of cell cycle progression to promote esophageal squamous cell carcinoma cell proliferation.EBioMedicine.2018Nov;37:110-124. IF:8.143
17. Lei?Li#,?Hong?Yang#,?Yan?Li1,?Xiao-Dong?Li,?TingTing?Zeng,?Su-Xia?Lin,?Ying-Hui?Zhu*?and?XinYuan?Guan*.Hypoxia?restrains?the?expression?ofcomplement?component?9?in?tumorassociated?macrop-hages promotingnon small?cell?lungcancer?progression.Cell?Death?Discovery.2018;4(63):2-12. IF:5.241
18. Jianwei Wang #, Min Liu #, Jingxian Shen# , Haichao Ouyang #, Xiuying Xie#, Ting Lin#, Anhua Li*and Hong Yang *.Diagnostic value of intraoperative ultrasonography in assessing thoracic recurrent laryngeal nerve lymph nodes in patients with esophageal cancer.BMC Cancer. 2018 July;18(1):737. IF:4.43
19. Jing-Sheng Zeng, Zhen-Dong Zhang, Li Pei, Zhi-Zhu Bai, Yong Yang, Hong Yang*,Qiu-Hong Tian*.CBX4 exhibits oncogenic activities in breast cancer via Notch1 signaling.Int J Biochem Cell Biol. 2018 Feb;95:1-8. IF:5.058
20. Bo Qiu#, JiaXiang Li# , Bin Wang# , ZhiQiang Wang, Ying Liang , Peiqiang Cai, ZhaoLin Chen , MengZhong Liu, JianHua Fu，?Hong Yang*, Hui Liu*.Adjuvant Therapy for a Microscopically Incomplete Resection Margin after an Esophagectomy for Esophageal Squamous Cell Carcinoma.J Cancer.2017 Jan;8(2):249-257. IF:4.207
21. Liu M#, Hu Y#, Zhang MF#, Luo KJ, Xie XY, Wen J, Fu JH, Yang H*.MMP1 promotes tumor growth and metastasis in esophageal squamous cell carcinoma.Cancer Lett.2016 July;377(1):97-104. IF:8.679
22. Bo Qiu#, De Ling Wang#, Hong Yang#, Wei Hao Xie, Ying Liang, Pei qiang Cai ZhaoLin 19.Chen, Meng Zhong Liu, JianHua Fu, Chuan Miao Xie*, Hui Liu*Combined modalities of magnetic resonance imaging, endoscopy and computed tomography in the evaluation of tumor responses to definitive chemoradiotherapy in esophageal squamous cell carcinoma. Radiotherapy and Oncology. 2016 Nov;121(2):239-245. IF: 6.28
23. Song Ran Liu#, Bo Qiu#, Hong Yang#, Ying Liang, Fang Wang, Shi Liang Liu, Zhao Lin Chen, Li Zhang, Meng Zhong Liu, Si Yu Wang, Lan Feng Lin*, and Hui Liu*.Epidermal Growth Factor Receptor Mutation Status and Treatment Outcome for R0-Resected Patients with Stage 3 Non-small Cell Lung Cancer.Ann Surg Oncol. 2016 Jan;23(6):2115-22. IF:5.344
24. Liu SL#, Yang H#, Zhang P#, Zhang L, Zhao L, Luo LL, Fu JH, Liu MZ, Xi M*.Neoadjuvant chemoradiotherapy with cisplatin plus vinorelbine versus cisplatin plus fluorouracil for esophageal squamous cell carcinoma: A matched case-control study. Radiotherapy and Oncology. 2016;121(2):239~245. IF:6.28
25. Huang QY#, Luo KJ#, Yang H#, Wen J, Zhang SS, Li JH, Bella AE, Liu QW, Yang F, Zheng YZ, Hu RG,Chen JY, Fu JH*. Impact of alcohol consumption on survival in patients with esophageal carcinoma:a large cohort with long-term follow-up.Cancer Sci. 2014;105(12):1638-1646. IF:6.419
26. Wen J#, Yang H#, Liu MZ#, Luo KJ, Liu H, Hu Y, Zhang X, Lai RC, Lin T, Wang HY, Fu JH*.Gene expression analysis of pretreatment biopsies predicts the pathological response of esophageal squamous cell carcinomas to neo-chemoradiotherapy.Ann Oncol.2014;25（9）:1769~1774. IF:32.924
27. Zhang SS#, Yang H#, Luo KJ#, Huang QY, Chen JY, Yang F, Cai XL, Xie X, Liu QW, Bella AE, Hu RG, Wen J, Hu Y, Fu JH(*).The impact of body mass index on complication and survival in resected oesophageal cancer: a clinical-based cohort and meta-analysis.Br J Cancer.2013;109(11)：2894~2903. IF:7.64
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更新時間：2024.12.13"
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民福康號公眾號
民?？滇t(yī)生小程序
