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string(7473) "黃常志,男,1956年12月出生于廣東省湛江市?,F(xiàn)任中國醫(yī)學科學院腫瘤醫(yī)院腫瘤研究所,北京協(xié)和醫(yī)學院(清華大學醫(yī)學部),二級教授/研究員,博士生導師,北京協(xié)和醫(yī)學院學位分委會委員,腫瘤學教研室常務副主任。分子腫瘤學國家重點實驗室PI (Principle Investigator),“癌發(fā)生及預防分子機理” 北京市重點實驗室PI研究員,北京協(xié)和醫(yī)學院生物化學系研究員。西南交通大學兼職教授;廣東醫(yī)學院客座教授;北京生物化學與分子生物學會理事;中國抗癌協(xié)會病因?qū)I(yè)委員會委員;生物化學與生物物理進展、中華腫瘤防治雜志等雜志編委。
1982年畢業(yè)于武漢大學生物系生物化學專業(yè)。同年進入北京協(xié)和醫(yī)學院中國醫(yī)學科學院腫瘤醫(yī)院腫瘤研究所。1983年在中國科學院上海細胞生物學研究所進修學習。1990-1994年留學加拿大Dalhousie大學生物化學與分子生物學系,1999年在加拿大Dalhousie大學生物化學與分子生物學系訪問教授。承擔過的課題:國家自然科學基金,衛(wèi)生部科研基金,人事部科研基金,中國醫(yī)學科學院科研基金,北京市重大科研項目子課題和國家科技部973,863課題等研究項目。參加過“六五”“七五”“八五”“九五”國家腫瘤攻關課題研究?,F(xiàn)在領導的科研課題組,從事基因結構與功能,腫瘤發(fā)病機理,腫瘤基因治療和免疫治療研究。在國內(nèi)外科學雜志共發(fā)表研究論文70多篇,參與編寫專著四部。1990年獲中國醫(yī)學科學院成果一等獎,1995年獲北京市青年優(yōu)秀科技論文三等獎。負責北京協(xié)和醫(yī)學院本科生和研究生“腫瘤學”、“現(xiàn)代分子生物學實驗技術”的教學工作。培養(yǎng)了碩士博士研究生20多名。
2010年以來發(fā)表的論文
1. 羅清, 趙玫, 時嵐, 馬怡茗, 鐘佳伶, 黃常志*. 人細胞核誘導凋亡因子1在大腸桿菌中的表達、純化及多克隆抗體制備. 細胞與分子免疫學雜志, 2010; 26(1): 56-58.
2. 孫曉杰, 周啟兵, 黃常志﹡. 血清和糖皮質(zhì)激素調(diào)節(jié)蛋白激酶2α過表達通過Wnt/β-Catenin信號通路抑制肝癌細胞株BEL7402增殖. 生物化學與生物物理進展, 2010; 37(5): 496-502.
3. 孫曉杰, 周啟兵, 趙玫, 李珅, 吳琦, 郭艷紅, 黃常志*. 蛋白激酶SGK2α在大腸桿菌中的表達純化及抗體制備. 中國現(xiàn)代醫(yī)學雜志, 2010; 20(12): 1765-1768.
4. 王曉霞, 趙玫, 趙新華, 蔡恬靜, 袁興華, 余權, 黃常志﹡. 骨唾液酸蛋白與乳腺癌細胞黏附性的相關性. 中國腫瘤, 2010; 19(7): 477-482.
5. 羅 清, 鐘佳玲, 趙 玫, 馬怡茗, 劉 健, 王 佳, 黃常志*. 利用pTet-Off系統(tǒng)研究NAIF1對食管癌細胞系EC9706生物學行為的影響. 細胞與分子免疫學雜志, 2010; 20(12): 1765-1768.
6. 馬怡茗, 趙玫, 時嵐, 羅清, 鐘佳伶, 劉健, 王佳, 黃常志*. 結腸癌蛋白質(zhì)雙向電泳技術的建立. 現(xiàn)代生物醫(yī)學進展, 2010; 10(9): 1601-1603.
7. Shi L, Zhao M, Yuan X, Huang C*. Overexpression of PIP5KL1 suppresses the growth of human cervical cancer cells in vitroin vivo. Cell Biol Int. 2010; 34: 309-315.
8. Shi L, Zhao M, Luo Q, Ma YM, Zhong JL, Yuan XH, Huang CZ*. Overexpression of PIP5KL1 suppresses cell proliferationmigration in human gastric cancer cells. Mol Biol Rep. 2010; 37: 2189-2198.
9. Ma Y, Zhao M, Zhong J, Shi L, Luo Q, Liu J, Wang J, Yuan X, Huang C*. Proteomic profiling of proteins associated with lymph node metastasis in colorectal cancer. J Cell Biochem. 2010; 110(6): 1512-1519.
10. Qing Luo, Mei Zhao, Jialing Zhong, Yiming Ma, Guohua Deng, Jian Liu, Jia Wang, Xinghua Yuan, Changzhi Huang*. NAIF1 is down-regulated in gastric cancercan promote apoptosis through caspase-9 pathway in human MKN45 cells, Oncol Rep. 2011; 25(4): 1117-1123.
11. Zhong J, Zhao M, Ma Y, Luo Q, Liu J, Wang J, Yuan X, Sang J, Huang C﹡. UCHL1 acts as a colorectal cancer oncogene via activation of the β-catenin/TCF pathway through its deubiquitinating activity. Int J Mol Med. 2012; 30(2): 430-436.
12. Zhong J, Zhao M, Luo Q, Ma Y, Liu J, Wang J, Yang M, Yuan X, Sang J, Huang C*. CCDC134 is down-regulated in gastric cancerits silencing promotes cell migrationinvasion of GES-1AGS cells via the MAPK pathway. Mol Cell Biochem. 2013; 372(1-2): 1-8.
13. Jia Wang, Sheng-kai Huang, Mei Zhao, Mei Yang, Jia-ling Zhong, Yu-yu Gu, Hua Peng, Yi-qun Che2*, Chang-zhi Huang1*. Identification of a Circlating MicroRNA Signature for Colorectal Cancer Detection. PLOS ONE 2014; 9(4): e87451. IF:3.534
14. Jian Liu, Haijuan Wang, Changzhi Huang*, Haili Qian*. Subcellular localization of MTA proteins in normalcancer cells Cancer metastasis Rev. 2014; 33(4): 843-856. IF:6.449
15. Mei Yang, Jialing Zhong, Mei Zhao, Jia Wang, Yuyu Gu, Xinghua Yuan, Jianli Sang, Changzhi Huang*. Overexpression of Nuclear Apoptosis-Inducing Factor 1 Altered the Proteomic Profile of Human Gastric Cancer Cell MKN45Induced Cell Cycle Arrest at G1/S Phase. PLOS ONE 2014; 9(6): e100216. IF:3.534
16. Jian Liu, Dongkui Xu, Haijuan Wang, Ying Zhang, Yanan Chang, Jinlong Zhang, Jia Wang, Chunxiao Li, Huan Liu, Mei Zhao, Chen Lin, Qimin Zhan*, Changzhi Huang*Haili Qian*. The subcellular distributionfunction of MTA1 in cancer differentiation. Oncotarget, 2014; 5(13): 5153-5164. IF:6.627
17. Jian Liu, Haijuan Wang, Fei Ma, Dongkui Xu, Yanan Chang, Jinlong Zhang, Jia Wang, Mei Zhao, Chen Lin, Changzhi Huang**, Haili Qian*, Qimin Zhan**. MTA1 regulates higher-order chromatin structurehistone H1-chromatin interaction in-vivo. Molecular Oncology 2014; Pii: S1574-7891(14)00202-6. IF:5.935
18. Mei Yang, Yu-yu Gu, Hua Peng, Mei Zhao, Jia Wang, Sheng-kai Huang, Xing-hua Yuan, Jia Li, Jian-li Sang, Qing Luo, Changzhi Huang*. NAIF1 inhibits gastric cancer cells migrationinvasion via the MAPK pathways. J Cancer Res Clin Oncol published online: 29 November 2014 IF:3.0
19. Yunping Qiu, Guoxiang Cai, Bingsen Zhou, Dan Li, Aihua Zhao, Guoxiang Xie, Houkai Li, Sanjun Cai, Dong Xie, Changzhi Huang, Weiting Ge, Zhanxiang Zhou, Lisa X. Xu, Weiping Jia, Shu Zheng, Yun Yen,Wei Jia. A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential. Clin Cancer Res. 2014; 20(8): 2136-2146. IF:7.338
20. 劉健, 王海娟, 劉群, 李春曉, 劉歡, 黃驍舾, 孟希亭, 趙玫, 林晨, 黃常志*,錢海利*. In situ PLA 技術原位分析MTA1與NuRD 復合體其他組分的相互作用. 癌癥進展, 2014; 4(12): 394-398.
21. Yi-Qun Che, Lin Feng, Wei-Qi Rong, Di Shen, Qian Wang, Lin Yang, Jun Qi, Chang-Zhi Huang*. Correlation analysis of peripheral blood T cell subgroups, immunoglobulinprognosis of early hepatocellular carcinoma after hepatectomy. Int J Clin Exp Med 2014; 7(11): 4282-4290.
22. Yu-yu Gu, Mei Yang, Mei Zhao, Qing Luo, Lin Yang, Hua Peng, Jia Wang, Sheng-kai Huang, Zhao-xu Zheng, Xing-hua Yuan, Ping Liu, Chang-zhi Huang. The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the AktErk1/2 pathways; Tumor Biol. 2015; DOI 10.1007/s13277-015-3566-0
23. 彭華, 黃常志. 代謝組學在腫瘤診斷和治療中的研究進展.中華腫瘤雜志, 2015; 37(2): 81-83.
24. 谷愉愉, 趙玫, 楊梅, 王佳, 彭華, 黃聲凱, 李佳, 桑建利, 袁興華, 黃常志*. NAIF1對肝癌細胞HepG2增殖與遷移能力的影響. 現(xiàn)代生物醫(yī)學進展, 2015; 15(6): 1001-1004."
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